4 compounds
Cellular
Mitochondrial, antioxidant and immune-signalling research
THIOL
L-Glutathione
Studied as the principal intracellular antioxidant in redox-balance and detoxification-pathway research.
REDOX
NAD+
Studied as a central redox cofactor in mitochondrial metabolism and sirtuin-pathway research.
CRISTAE
SS-31 (Elamipretide)
Studied for its association with cardiolipin on the inner mitochondrial membrane in bioenergetics research.
PRAETORIAN
Thymosin Alpha-1
Studied in T-cell maturation and innate immune-signalling research models.
Cellular research
What the published literature on these compounds actually examined — the model, the endpoint, and the result.
Cellular
What a peptide actually is
Short chains of amino acids, the signalling vocabulary biology already speaks, and why they became one of the most active areas in drug discovery.
Cellular
Mitochondrial peptides, cardiolipin and the NAD+ pool
The mitochondrial genome encodes signalling peptides of its own. Separately, a class of compounds targets the inner membrane directly.
Cellular
Thymic peptides: an immunomodulator with a long paper trail
Thymosin alpha-1 has been studied since the 1970s, is licensed in a number of countries, and has a mechanistic account centred on Toll-like receptor signalling.